FBXO6

Across TCGA patient cohorts, FBXO6 mutation is significantly associated with the RNA expression of many other genes, with 923 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXO6-associated genes across cancer lineages are C5orf64, CCDC89, and PRF1. Each is linked with FBXO6 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXO6-to-partner and partner-to-FBXO6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C5orf64 grouped by FBXO6-low versus FBXO6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO6→partner) and Y-score (partner→FBXO6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C5orf64 →	+0.066	+2.494	.002	.005	3	1
UCEC	CCDC89 →	-0.775	-2.700	.006	.006	3	1
UCEC	PRF1 →	+1.818	+3.708	<.001	<.001	3	1
UCEC	PITPNB →	+0.434	+3.839	.008	<.001	3	1
UCEC	TIGIT →	+1.409	+3.600	<.001	.001	3	1
UCEC	LCK →	+1.072	+3.332	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 923 associations by consensus.

C5orf64 by FBXO6 expression — UCEC

Explore this box plot interactively →