FBXO6

Across TCGA pan-cancer cohorts, FBXO6 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated FBXO6 data layer compared with 2 for mutation status and 8 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher FBXO6 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated FBXO6 expression acts as an unfavorable survival marker, although some lineages such as BLCA and SKCM show a favorable association.

KICH, BLCA, and SKCM are the cancer types where FBXO6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Tertile	II,III,IV	0.297	1.000	<.001	93	view →
BLCA	DFS	Tertile	All	0.421	0.209	<.001	70	view →
SKCM	OS	Tertile	All	0.489	0.287	<.001	56	view →
KIRC	OS	Median	All	0.840	0.919	.003	44	view →
LGG	OS	Median	All	0.351	0.533	<.001	38	view →
OV	OS	Median	All	0.738	0.638	.003	30	view →
LIHC	DFS	Quartile	All	0.366	0.640	.004	30	view →
LUAD	OS	Quartile	II,III,IV	0.657	0.439	.010	22	view →
BRCA	DFS	Quartile	All	0.638	0.525	.001	20	view →
CHOL	DFS	Quartile	All	0.678	0.178	.010	16	view →
COAD	DFS	Quartile	All	0.663	0.407	.017	14	view →
THYM	OS	Median	All	0.716	0.969	.004	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

FBXO6–KICH (DFS)

Open the KICH breakdown →