FBXO5

Across TCGA patient cohorts, FBXO5 mutation is significantly associated with the RNA expression of many other genes, with 815 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXO5-associated genes across cancer lineages are GJA1P1, MIR599, and RNU6-1140P. Each is linked with FBXO5 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXO5-to-partner and partner-to-FBXO5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GJA1P1 grouped by FBXO5-low versus FBXO5-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO5→partner) and Y-score (partner→FBXO5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GJA1P1 →	+0.307	+2.993	<.001	.009	3	2
CESC	MIR599 →	+0.475	+6.144	<.001	.001	3	2
CESC	RNU6-1140P →	+0.367	+5.539	<.001	.004	3	2
CESC	DNAJA1P1 →	+0.053	+5.306	<.001	.006	3	2
COAD	RNU4-58P →	+0.269	+5.412	<.001	.001	3	2
UCEC	RNA5SP297 →	+0.326	+1.859	.004	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 815 associations by consensus.

GJA1P1 by FBXO5 expression — COAD

Explore this box plot interactively →