FBXO43

Across TCGA patient cohorts, FBXO43 mutation is significantly associated with the RNA expression of many other genes, with 2,897 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXO43-associated genes across cancer lineages are UQCRC1, ACO2, and SLC25A11. Each is linked with FBXO43 in more than 2 cancer types. Because this analysis shows association rather than direction, both FBXO43-to-partner and partner-to-FBXO43 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UQCRC1 grouped by FBXO43-low versus FBXO43-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO43→partner) and Y-score (partner→FBXO43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	UQCRC1 →	+0.692	+3.334	<.001	.005	3	3
UCEC	ACO2 →	+0.646	+2.337	<.001	<.001	3	3
UCEC	SLC25A11 →	+0.346	+3.891	.001	<.001	3	3
UCEC	PSMD9 →	+0.404	+2.058	<.001	<.001	3	3
UCEC	GOT1 →	+0.439	+3.286	<.001	<.001	3	3
UCEC	CYSTM1 →	+0.515	+2.410	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,897 associations by consensus.

UQCRC1 by FBXO43 expression — SKCM

Explore this box plot interactively →