FBXO43

Across TCGA pan-cancer cohorts, FBXO43 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated FBXO43 data layer compared with 6 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher FBXO43 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated FBXO43 expression acts as an unfavorable survival marker, although some lineages such as THYM and UCS show a favorable association.

ACC, KIRP, and KIRC are the cancer types where FBXO43 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.222	0.682	<.001	139	view →
KIRP	DFS	Median	All	0.753	0.952	<.001	128	view →
KIRC	DFS	Median	All	0.532	0.713	<.001	124	view →
LIHC	DFS	Median	All	0.380	0.489	<.001	108	view →
KICH	DFS	Median	All	0.647	0.954	<.001	108	view →
MESO	OS	Quartile	All	0.365	0.722	<.001	100	view →
UVM	DFS	Tertile	All	0.305	0.816	<.001	94	view →
LGG	DFS	Median	All	0.660	0.817	<.001	51	view →
LUAD	OS	Quartile	All	0.752	0.882	.009	36	view →
SARC	OS	Median	All	0.401	0.620	.003	28	view →
THCA	OS	Tertile	III,IV	0.643	1.000	.009	25	view →
PRAD	DFS	Median	All	0.836	0.931	<.001	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

FBXO43–ACC (DFS)

Open the ACC breakdown →