FBXO43

Across TCGA pan-cancer cohorts, FBXO43 RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of FBXO43’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where FBXO43 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FBXO43 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

KIRC, LUAD, and HNSC are the cancer types where FBXO43 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FBXO43 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+0.326	<.001	11	view →
LUAD	Male	All	+0.655	<.001	10	view →
HNSC	All	III,IV	+0.374	<.001	10	view →
LIHC	Male	All	+0.837	<.001	8	view →
UCEC	All	All	+0.549	<.001	8	view →
STAD	All	II,III,IV	+0.433	<.001	8	view →
KIRP	All	III,IV	+0.406	<.001	8	view →
THCA	All	All	−0.166	<.001	8	view →
LUSC	Female	All	+0.988	<.001	7	view →
COAD	All	II,III,IV	+0.167	<.001	7	view →
BRCA	All	III,IV	+0.630	<.001	6	view →
CHOL	All	All	+0.803	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

FBXO43–KIRC

Open the KIRC breakdown →