FBXO43

Across TCGA patient cohorts, FBXO43 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXO43-associated genes across cancer lineages are ATM, Paxillin, and AMPK_alpha. Each is linked with FBXO43 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXO43-to-partner and partner-to-FBXO43 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by FBXO43-low versus FBXO43-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO43→partner) and Y-score (partner→FBXO43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ATM →	-0.774	-2.991	<.001	.036	3	2
COAD	Paxillin →	-0.383	-2.991	.037	.036	3	1
COAD	AMPK_alpha →	-0.201	-2.957	.031	.036	3	1
COAD	PKC-b-II_pS660 →	-0.525	-2.991	.004	.036	2	2
COAD	RAD51 →	+0.186	+3.008	.022	.019	3	1
COAD	ARID1A →	+0.181	+3.000	.040	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

ATM by FBXO43 expression — COAD

Explore this box plot interactively →