FBXO43

Across TCGA cell cohorts, FBXO43 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,952 significant associations in total. BONE shows the largest number of these associations.

The most reproducible FBXO43-associated GO terms across cancer lineages are Mitotic spindle assembly checkpoint signaling, Spindle assembly checkpoint signaling, and Mitotic spindle checkpoint signaling. Each is linked with FBXO43 in more than 16 cancer types. Because this analysis shows association rather than direction, both FBXO43-to-partner and partner-to-FBXO43 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitotic spindle assembly checkpoint signaling grouped by FBXO43-low versus FBXO43-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO43→partner) and Y-score (partner→FBXO43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Mitotic spindle assembly checkpoint signaling →	+0.156	+0.965	<.001	<.001	3	17
BREAST	Spindle assembly checkpoint signaling →	+0.156	+0.965	<.001	<.001	3	17
BREAST	Mitotic spindle checkpoint signaling →	+0.156	+0.965	<.001	<.001	3	17
BREAST	Negative regulation of metaphase/anaphase transition of cell cycle →	+0.140	+0.930	<.001	<.001	3	16
BREAST	Regulation of chromosome separation →	+0.158	+1.026	<.001	<.001	3	16
BREAST	Negative regulation of chromosome separation →	+0.140	+0.930	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,952 associations by consensus.

Mitotic spindle assembly checkpoint signaling by FBXO43 expression — BREAST

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