FBXO43

Across TCGA cell cohorts, FBXO43 mutation is significantly associated with the drug of many other genes, with 21 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FBXO43-associated genes across cancer lineages are LCL161, GSK2801, and WZ3105. Each is linked with FBXO43 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXO43-to-partner and partner-to-FBXO43 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LCL161 grouped by FBXO43-low versus FBXO43-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO43→partner) and Y-score (partner→FBXO43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LCL161 →	+0.410	+2.672	.011	.039	3	1
LARGE_INTESTINE	GSK2801 →	+0.318	+2.649	.046	.046	3	1
LARGE_INTESTINE	WZ3105 →	+0.874	+2.652	.010	.045	3	1
LARGE_INTESTINE	CD532 →	+0.612	+2.652	.001	.045	3	1
LARGE_INTESTINE	SGC-CBP30 →	+0.344	+2.649	.014	.046	2	1
LARGE_INTESTINE	GSK2110183B →	+0.660	+2.649	.030	.046	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

LCL161 by FBXO43 expression — LARGE_INTESTINE

Explore this box plot interactively →