FBXO4

Across TCGA patient cohorts, FBXO4 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,240 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible FBXO4-associated proteins across cancer lineages are FBXO4_S12, C5orf51, and WDR70. Each is linked with FBXO4 in more than 6 cancer types. Because this analysis shows association rather than direction, both FBXO4-to-partner and partner-to-FBXO4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FBXO4 versus FBXO4_S12 in PDAC, with a Pearson correlation of 0.32.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO4→partner) and Y-score (partner→FBXO4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	FBXO4_S12 →	+0.655	+0.333	<.001	.005	3	7
LSCC	C5orf51 →	+0.243	+0.541	<.001	<.001	3	5
LSCC	WDR70 →	+0.310	+0.462	<.001	<.001	3	4
OV	GOLPH3 →	+0.367	+0.529	.006	.007	2	5
LSCC	PAIP1 →	+0.306	+0.495	<.001	<.001	3	4
LUAD	DAP →	+0.289	+0.381	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,240 associations by consensus.

FBXO4 vs FBXO4_S12 — PDAC

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