FBXO4

Across TCGA pan-cancer cohorts, FBXO4 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated FBXO4 data layer compared with 5 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher FBXO4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated FBXO4 expression acts as an unfavorable survival marker, although some lineages such as OV and KIRC show a favorable association.

UVM, KICH, and OV are the cancer types where FBXO4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Quartile	All	0.289	0.794	<.001	108	view →
KICH	DFS	Quartile	II,III,IV	0.403	0.928	.004	63	view →
OV	OS	Quartile	III,IV	0.937	0.762	.001	62	view →
LGG	OS	Median	All	0.714	0.905	<.001	54	view →
KIRC	DFS	Quartile	III,IV	0.667	0.268	<.001	52	view →
SKCM	OS	Quartile	All	0.375	0.211	<.001	51	view →
LUSC	DFS	Quartile	All	0.774	0.632	.006	20	view →
LIHC	DFS	Quartile	All	0.446	0.630	.001	17	view →
READ	OS	Quartile	All	0.981	0.845	.010	13	view →
KIRP	DFS	Median	All	0.801	0.902	.010	9	view →
BRCA	OS	Quartile	III,IV	0.942	0.798	.005	8	view →
UCS	DFS	Quartile	III,IV	0.543	0.121	.043	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

FBXO4–UVM (DFS)

Open the UVM breakdown →