FBXO27

Across TCGA cell cohorts, FBXO27 mutation is significantly associated with the mutation status of many other genes, with 10 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible FBXO27-associated genes across cancer lineages are ITGA5, ASB5, and CATSPER1. Each is linked with FBXO27 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXO27-to-partner and partner-to-FBXO27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ITGA5 grouped by FBXO27-low versus FBXO27-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO27→partner) and Y-score (partner→FBXO27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ITGA5 →	+5.502	+5.502	.003	.003	1	1
LUNG_SCLC	ASB5 →	+4.502	+5.066	.007	.007	1	1
LUNG_SCLC	CATSPER1 →	+4.502	+5.066	.007	.007	1	1
LUNG_SCLC	ZNF626 →	+4.502	+5.066	.007	.007	1	1
LUNG_SCLC	OR4E2 →	+4.502	+5.066	.007	.007	1	1
LUNG_SCLC	SDHA →	+4.502	+5.066	.007	.007	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

ITGA5 by FBXO27 expression — LUNG_SCLC

Explore this box plot interactively →