FBXO27

Across TCGA pan-cancer cohorts, FBXO27 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of FBXO27’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where FBXO27 RNA is repressed in tumor relative to normal tissue. In most cancer types FBXO27 is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.

THCA, HNSC, and LUSC are the cancer types where FBXO27 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FBXO27 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.685	<.001	9	view →
HNSC	All	All	+0.753	<.001	8	view →
LUSC	All	All	+2.019	<.001	6	view →
BRCA	All	II,III,IV	−0.744	<.001	6	view →
COAD	All	All	−0.621	<.001	6	view →
KIRP	All	III,IV	−0.985	.003	5	view →
KICH	All	All	−0.789	<.001	5	view →
READ	Female	All	−1.478	.008	4	view →
STAD	All	All	−0.934	.006	4	view →
LIHC	All	All	+0.662	<.001	3	view →
LUAD	Male	III,IV	+1.023	.013	2	view →
PAAD	All	All	+0.987	.027	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

FBXO27–THCA

Open the THCA breakdown →