FBXO10

Across TCGA cell cohorts, FBXO10 mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FBXO10-associated genes across cancer lineages are DEFA1, NAT8B, and C1QC. Each is linked with FBXO10 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXO10-to-partner and partner-to-FBXO10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFA1 grouped by FBXO10-low versus FBXO10-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO10→partner) and Y-score (partner→FBXO10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	DEFA1 →	+0.376	+3.196	<.001	.004	3	2
LUNG_NSCLC_LUAD	NAT8B →	+0.084	+4.371	<.001	.005	3	2
SKIN	C1QC →	+0.027	+4.196	<.001	.002	3	1
SKIN	C1QA →	+0.063	+3.793	.003	.007	3	1
SKIN	KRTAP5-5 →	+0.014	+4.437	<.001	.004	3	1
SKIN	PIGY →	+2.914	+3.920	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

DEFA1 by FBXO10 expression — CNS

Explore this box plot interactively →