FBXO10

Across TCGA pan-cancer cohorts, FBXO10 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated FBXO10 data layer compared with 11 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher FBXO10 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated FBXO10 expression acts as an unfavorable survival marker, although some lineages such as PAAD and GBM show a favorable association.

ACC, UVM, and LIHC are the cancer types where FBXO10 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.412	0.882	<.001	129	view →
UVM	DFS	Tertile	All	0.294	0.809	<.001	120	view →
LIHC	OS	Tertile	All	0.690	0.847	<.001	80	view →
MESO	OS	Tertile	All	0.214	0.695	.001	65	view →
COAD	DFS	Tertile	II,III,IV	0.688	0.820	.005	49	view →
PAAD	DFS	Quartile	All	0.487	0.215	.001	48	view →
ESCA	DFS	Median	IV	0.205	0.634	.006	36	view →
GBM	DFS	Median	All	0.377	0.184	.003	20	view →
SARC	OS	Tertile	All	0.321	0.627	.004	17	view →
LUSC	DFS	Tertile	III,IV	0.497	1.000	.027	12	view →
SCLC	OS	Median	II,III,IV	0.978	0.443	.012	10	view →
LGG	OS	Tertile	All	0.935	0.822	.005	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

FBXO10–ACC (OS)

Open the ACC breakdown →