FBXL8

Across TCGA patient cohorts, FBXL8 mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXL8-associated genes across cancer lineages are ATP5MGP6, MIR6857, and OR6R2P. Each is linked with FBXL8 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXL8-to-partner and partner-to-FBXL8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATP5MGP6 grouped by FBXL8-low versus FBXL8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXL8→partner) and Y-score (partner→FBXL8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATP5MGP6 →	+0.408	+3.097	<.001	.004	3	2
UCEC	MIR6857 →	+0.364	+3.358	.001	.006	3	2
UCEC	OR6R2P →	+0.367	+3.061	<.001	.002	3	1
UCEC	ZYXP1 →	+0.172	+4.069	.006	.008	3	1
UCEC	VN1R7P →	+0.229	+3.245	.008	.001	3	1
COAD	C2orf69P4 →	+0.084	+7.741	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

ATP5MGP6 by FBXL8 expression — UCEC

Explore this box plot interactively →