FBXL8

Across TCGA pan-cancer cohorts, FBXL8 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of FBXL8’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where FBXL8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FBXL8 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

KIRC, BLCA, and COAD are the cancer types where FBXL8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FBXL8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+1.280	<.001	12	view →
BLCA	All	All	+1.013	<.001	11	view →
COAD	Male	III,IV	+0.908	<.001	10	view →
KIRP	Female	All	+0.835	<.001	9	view →
LIHC	Female	II,III,IV	+1.011	<.001	8	view →
STAD	Male	All	+0.775	<.001	6	view →
HNSC	Male	III,IV	+0.591	.004	6	view →
CHOL	All	All	+1.792	<.001	5	view →
LUAD	Female	All	+0.365	.004	3	view →
PAAD	All	All	+0.720	.015	2	view →
PRAD	All	All	+0.659	<.001	2	view →
KICH	All	All	−0.473	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

FBXL8–KIRC

Open the KIRC breakdown →