FBXL18

Across TCGA patient cohorts, FBXL18 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXL18-associated genes across cancer lineages are ATM, PKC-b-II_pS660, and 4E-BP1_pS65. Each is linked with FBXL18 in more than 2 cancer types. Because this analysis shows association rather than direction, both FBXL18-to-partner and partner-to-FBXL18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by FBXL18-low versus FBXL18-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXL18→partner) and Y-score (partner→FBXL18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.467	-2.222	.015	.011	3	3
BRCA	PKC-b-II_pS660 →	+0.334	+2.814	.036	.037	3	2
BRCA	4E-BP1_pS65 →	+0.316	+2.814	.005	.037	3	2
UCEC	MEK1 →	+0.418	+2.584	.007	.010	3	2
UCEC	p62 Lck ligand →	+0.543	+2.710	<.001	.003	3	2
UCEC	YAP →	+0.140	+3.013	.028	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

ATM by FBXL18 expression — UCEC

Explore this box plot interactively →