FBXL18

Across TCGA pan-cancer cohorts, FBXL18 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of FBXL18’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where FBXL18 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FBXL18 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, COAD, and LIHC are the cancer types where FBXL18 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FBXL18 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.904	<.001	12	view →
COAD	Female	All	+0.488	<.001	10	view →
LIHC	Female	All	+1.073	<.001	9	view →
LUAD	All	III,IV	+0.991	<.001	9	view →
THCA	Male	III,IV	−0.831	<.001	9	view →
LUSC	Male	II,III,IV	+0.961	<.001	7	view →
STAD	All	II,III,IV	+0.950	<.001	6	view →
CHOL	All	All	+1.691	<.001	5	view →
READ	All	III,IV	+1.190	.005	2	view →
BLCA	All	All	+0.456	.023	2	view →
PRAD	All	All	+0.315	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

FBXL18–HNSC

Open the HNSC breakdown →