FBXL18

Across TCGA pan-cancer cohorts, FBXL18 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated FBXL18 data layer compared with 5 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher FBXL18 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated FBXL18 expression acts as an unfavorable survival marker, although some lineages such as UCS and KIRC show a favorable association.

CESC, BLCA, and ACC are the cancer types where FBXL18 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Median	All	0.714	0.882	<.001	80	view →
BLCA	DFS	Quartile	All	0.166	0.570	<.001	60	view →
ACC	OS	Median	II,III,IV	0.360	0.807	<.001	45	view →
LIHC	DFS	Quartile	All	0.400	0.610	<.001	42	view →
THCA	OS	Quartile	II,III,IV	0.595	1.000	.005	37	view →
MESO	DFS	Median	All	0.268	0.457	.001	33	view →
UCS	OS	Tertile	IV	0.844	0.242	.024	26	view →
LGG	OS	Tertile	All	0.743	0.887	<.001	26	view →
KIRC	DFS	Tertile	All	0.807	0.502	<.001	25	view →
OV	OS	Quartile	All	0.795	0.870	.019	24	view →
LUAD	DFS	Quartile	IV	0.522	0.929	.008	21	view →
BRCA	DFS	Median	II,III,IV	0.921	0.959	.001	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

FBXL18–CESC (OS)

Open the CESC breakdown →