FBXL18

Across TCGA cell cohorts, FBXL18 mutation is significantly associated with the RNA expression of many other genes, with 1,321 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FBXL18-associated genes across cancer lineages are CDR1, TNRC6B, and SH3GL2. Each is linked with FBXL18 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXL18-to-partner and partner-to-FBXL18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDR1 grouped by FBXL18-low versus FBXL18-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXL18→partner) and Y-score (partner→FBXL18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CDR1 →	+0.134	+3.392	.008	.007	3	2
LARGE_INTESTINE	TNRC6B →	+0.779	+3.064	<.001	.009	3	2
LARGE_INTESTINE	SH3GL2 →	+1.398	+2.667	<.001	.007	3	2
LARGE_INTESTINE	UFSP2 →	+0.622	+3.364	<.001	.002	3	2
LARGE_INTESTINE	KDSR →	+0.857	+3.364	<.001	.002	3	2
LARGE_INTESTINE	YWHAH →	+0.557	+3.364	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,321 associations by consensus.

CDR1 by FBXL18 expression — OESOPHAGUS

Explore this box plot interactively →