FBXL18

Across TCGA cell cohorts, FBXL18 mutation is significantly associated with the mutation status of many other genes, with 7,044 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FBXL18-associated genes across cancer lineages are GAS2L2, BCORL1, and ABCC6. Each is linked with FBXL18 in more than 5 cancer types. Because this analysis shows association rather than direction, both FBXL18-to-partner and partner-to-FBXL18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAS2L2 grouped by FBXL18-low versus FBXL18-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXL18→partner) and Y-score (partner→FBXL18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	GAS2L2 →	+5.502	+5.502	.003	.003	1	6
SOFT_TISSUE	BCORL1 →	+5.502	+5.502	.003	.003	1	6
OVARY	ABCC6 →	+3.425	+3.204	<.001	<.001	1	6
LARGE_INTESTINE	ATG2A →	+1.564	+2.506	.003	.003	1	6
CNS	FBXO46 →	+5.044	+5.614	.003	.003	1	5
SKIN	ABCC3 →	+3.035	+3.321	.008	.008	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,044 associations by consensus.

GAS2L2 by FBXL18 expression — SOFT_TISSUE

Explore this box plot interactively →