FBXL12

Across TCGA patient cohorts, FBXL12 mutation is significantly associated with the RNA expression of many other genes, with 579 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXL12-associated genes across cancer lineages are OR7E53P, RNA5SP418, and LINC02559. Each is linked with FBXL12 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXL12-to-partner and partner-to-FBXL12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR7E53P grouped by FBXL12-low versus FBXL12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXL12→partner) and Y-score (partner→FBXL12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	OR7E53P →	+0.038	+2.273	.007	.006	3	2
UCEC	RNA5SP418 →	+0.822	+2.403	<.001	<.001	3	2
SKCM	LINC02559 →	+0.128	+4.624	<.001	.005	3	2
LUSC	SNORD114-15 →	+0.464	+7.924	<.001	.008	3	2
SKCM	MTCO1P54 →	+0.047	+3.623	.002	.006	3	2
SKCM	VN1R93P →	+0.065	+4.292	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 579 associations by consensus.

OR7E53P by FBXL12 expression — UCEC

Explore this box plot interactively →