FBXL12

Across TCGA pan-cancer cohorts, FBXL12 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated FBXL12 data layer compared with 4 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher FBXL12 RNA is associated with better overall survival. In most high-consensus cancer types, elevated FBXL12 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SCLC show a favorable association.

HNSC, ACC, and KIRP are the cancer types where FBXL12 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.459	0.307	<.001	122	view →
ACC	DFS	Median	All	0.224	0.663	<.001	109	view →
KIRP	DFS	Quartile	All	0.753	0.943	<.001	60	view →
SCLC	OS	Median	II,III,IV	0.717	0.401	.004	51	view →
LGG	DFS	Median	All	0.663	0.815	<.001	48	view →
BLCA	DFS	Tertile	All	0.697	0.544	.006	40	view →
KIRC	DFS	Median	All	0.872	0.715	<.001	34	view →
UCEC	OS	Tertile	IV	0.780	0.247	.003	32	view →
KICH	DFS	Quartile	III,IV	0.071	1.000	.010	29	view →
LIHC	DFS	Quartile	All	0.304	0.510	<.001	27	view →
LUSC	DFS	Median	III,IV	0.523	0.916	.009	25	view →
PRAD	DFS	Tertile	All	0.700	0.825	.003	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

FBXL12–HNSC (OS)

Open the HNSC breakdown →