FBRSL1

Across TCGA cell cohorts, FBRSL1 mutation is significantly associated with the RNA expression of many other genes, with 1,033 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FBRSL1-associated genes across cancer lineages are TMTC3, LRRC74A, and UGT2A1. Each is linked with FBRSL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both FBRSL1-to-partner and partner-to-FBRSL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMTC3 grouped by FBRSL1-low versus FBRSL1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBRSL1→partner) and Y-score (partner→FBRSL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TMTC3 →	+0.889	+3.129	<.001	<.001	3	3
SOFT_TISSUE	LRRC74A →	+0.015	+4.169	<.001	.002	3	2
LUNG_NSCLC_LUAD	UGT2A1 →	+0.538	+3.974	<.001	.005	3	2
LUNG_NSCLC_LUAD	IQCF3 →	+0.041	+4.813	<.001	<.001	3	2
CNS	KNG1 →	+0.009	+3.145	.002	.004	3	2
BREAST	GABRA6 →	+0.120	+2.830	.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,033 associations by consensus.

TMTC3 by FBRSL1 expression — LARGE_INTESTINE

Explore this box plot interactively →