FBRSL1

Across TCGA pan-cancer cohorts, FBRSL1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of FBRSL1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where FBRSL1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FBRSL1 is over-expressed in tumor.

HNSC, COAD, and LIHC are the cancer types where FBRSL1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FBRSL1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+1.014	<.001	10	view →
COAD	Female	II,III,IV	+0.975	<.001	10	view →
LIHC	Female	II,III,IV	+1.047	<.001	9	view →
LUSC	Male	III,IV	+1.464	<.001	7	view →
STAD	Male	II,III,IV	+1.160	<.001	6	view →
CHOL	Male	All	+1.720	<.001	5	view →
BRCA	All	II,III,IV	+0.190	.015	4	view →
KIRP	All	IV	+0.847	.045	2	view →
READ	All	All	+0.719	.006	2	view →
LUAD	All	III,IV	+0.518	.032	2	view →
KICH	All	II,III,IV	+0.461	.006	2	view →
UCEC	All	All	+0.328	.023	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

FBRSL1–HNSC

Open the HNSC breakdown →