FBN3

Across TCGA patient cohorts, FBN3 mutation is significantly associated with the RNA expression of many other genes, with 8,354 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBN3-associated genes across cancer lineages are ECHS1, ASF1B, and TYRP1. Each is linked with FBN3 in more than 4 cancer types. Because this analysis shows association rather than direction, both FBN3-to-partner and partner-to-FBN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ECHS1 grouped by FBN3-low versus FBN3-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBN3→partner) and Y-score (partner→FBN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	ECHS1 →	+0.472	+3.476	<.001	.002	3	5
LUAD	ASF1B →	+0.715	+3.602	.002	.001	3	5
LUAD	TYRP1 →	-0.635	-2.991	.007	<.001	3	5
STAD	FOXF2 →	-0.973	-2.568	.001	.009	3	5
LUAD	BAALC →	-1.097	-3.169	.001	<.001	3	5
LUAD	SCNN1B →	-1.342	-2.502	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,354 associations by consensus.

ECHS1 by FBN3 expression — STAD

Explore this box plot interactively →