FBN3

Across TCGA pan-cancer cohorts, FBN3 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated FBN3 data layer compared with 10 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher FBN3 RNA is associated with better overall survival. In most high-consensus cancer types, elevated FBN3 expression acts as an unfavorable survival marker, although some lineages such as UCS and HNSC show a favorable association.

UCS, HNSC, and COAD are the cancer types where FBN3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	OS	Tertile	II,III,IV	0.721	0.183	<.001	88	view →
HNSC	OS	Median	III,IV	0.431	0.320	.008	57	view →
COAD	DFS	Quartile	II,III,IV	0.648	0.854	.002	50	view →
LGG	OS	Tertile	All	0.723	0.874	<.001	40	view →
SCLC	DFS	Median	II,III,IV	0.504	0.173	.004	31	view →
BRCA	OS	Median	IV	0.291	0.810	<.001	30	view →
KIRC	OS	Median	II,III,IV	0.437	0.596	.006	28	view →
ACC	DFS	Median	All	0.296	0.600	.003	26	view →
UCEC	OS	Median	All	0.615	0.758	.016	22	view →
THCA	DFS	Median	All	0.930	0.622	.001	22	view →
THYM	DFS	Median	All	0.934	0.799	.007	21	view →
DLBC	OS	Median	II,III,IV	0.294	1.000	.007	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

FBN3–UCS (OS)

Open the UCS breakdown →