FAT2

Across TCGA cell cohorts, FAT2 mutation is significantly associated with the RNA expression of many other genes, with 1,600 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FAT2-associated genes across cancer lineages are ZNF286B, THOC1, and PIGBOS1. Each is linked with FAT2 in more than 3 cancer types. Because this analysis shows association rather than direction, both FAT2-to-partner and partner-to-FAT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF286B grouped by FAT2-low versus FAT2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAT2→partner) and Y-score (partner→FAT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZNF286B →	+0.589	+1.807	.009	.005	3	4
LUNG_NSCLC_LUAD	THOC1 →	+0.555	+2.056	<.001	.005	3	4
LUNG_NSCLC_LUAD	PIGBOS1 →	+0.466	+2.533	<.001	.002	3	4
SOFT_TISSUE	STAG1 →	+0.741	+3.214	.001	.006	3	3
SOFT_TISSUE	BDH2 →	+1.373	+3.303	.001	.004	3	3
BLOOD_Lymphoma	TTC25 →	+0.556	+2.584	.002	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,600 associations by consensus.

ZNF286B by FAT2 expression — LARGE_INTESTINE

Explore this box plot interactively →