FAT2

Across TCGA pan-cancer cohorts, FAT2 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated FAT2 data layer compared with 10 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher FAT2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated FAT2 expression acts as an unfavorable survival marker, although some lineages such as LAML and UCEC show a favorable association.

SKCM, KICH, and LIHC are the cancer types where FAT2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.719	0.840	<.001	107	view →
KICH	OS	Tertile	II,III,IV	0.540	1.000	<.001	68	view →
LIHC	OS	Quartile	III,IV	0.315	0.693	.001	33	view →
KIRP	OS	Tertile	All	0.864	0.960	.003	20	view →
KIRC	DFS	Quartile	All	0.495	0.680	.005	18	view →
HNSC	OS	Tertile	All	0.279	0.507	.006	18	view →
MESO	DFS	Tertile	III,IV	0.252	0.721	.010	18	view →
LAML	DFS	Quartile	All	0.732	0.380	.008	18	view →
UCEC	DFS	Tertile	IV	0.874	0.466	.010	16	view →
SCLC	DFS	Median	IV	0.137	0.559	.008	12	view →
BRCA	DFS	Median	All	0.585	0.454	.008	10	view →
READ	DFS	Median	IV	0.384	0.701	.024	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

FAT2–SKCM (OS)

Open the SKCM breakdown →