FASTKD3

Across TCGA cell cohorts, FASTKD3 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LUNG_NSCLC_LUSC shows the largest number of these associations.

The most reproducible FASTKD3-associated genes across cancer lineages are SMR3A, IL2, and CHIA. Each is linked with FASTKD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both FASTKD3-to-partner and partner-to-FASTKD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMR3A grouped by FASTKD3-low versus FASTKD3-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FASTKD3→partner) and Y-score (partner→FASTKD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	SMR3A →	+0.063	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	IL2 →	+0.049	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	CHIA →	+0.396	+4.643	.001	.008	3	1
LUNG_NSCLC_LUSC	OR1L3 →	+0.060	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	NLRP8 →	+0.023	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	FAM47B →	+0.036	+4.643	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

SMR3A by FASTKD3 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →