FASTKD3

Across TCGA pan-cancer cohorts, FASTKD3 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of FASTKD3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where FASTKD3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FASTKD3 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

KIRC, HNSC, and BLCA are the cancer types where FASTKD3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FASTKD3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	+1.024	<.001	12	view →
HNSC	All	III,IV	+0.953	<.001	12	view →
BLCA	Male	All	+1.177	<.001	11	view →
THCA	Male	IV	−0.919	<.001	10	view →
STAD	All	II,III,IV	+0.982	<.001	9	view →
LIHC	Male	All	+0.892	<.001	9	view →
LUAD	Male	All	+0.775	<.001	8	view →
BRCA	All	III,IV	+0.721	<.001	6	view →
LUSC	All	All	+0.751	<.001	5	view →
KICH	All	All	−0.702	<.001	5	view →
CHOL	Male	All	+1.308	<.001	4	view →
ESCA	All	All	+0.688	.004	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

FASTKD3–KIRC

Open the KIRC breakdown →