FASLG

Across TCGA patient cohorts, FASLG mutation is significantly associated with the RNA expression of many other genes, with 3,001 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FASLG-associated genes across cancer lineages are RAD23B, PCGF6, and FANCC. Each is linked with FASLG in more than 2 cancer types. Because this analysis shows association rather than direction, both FASLG-to-partner and partner-to-FASLG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAD23B grouped by FASLG-low versus FASLG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FASLG→partner) and Y-score (partner→FASLG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RAD23B →	+0.595	+3.169	<.001	<.001	3	3
UCEC	PCGF6 →	+0.551	+3.609	.001	.001	3	3
UCEC	FANCC →	+0.461	+3.202	.002	.009	3	3
UCEC	CDC25A →	+0.874	+3.169	<.001	<.001	3	3
UCEC	MYO19 →	+0.557	+3.724	<.001	<.001	3	2
UCEC	ARPC4 →	+0.422	+3.708	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,001 associations by consensus.

RAD23B by FASLG expression — UCEC

Explore this box plot interactively →