FASLG

Across TCGA pan-cancer cohorts, FASLG RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated FASLG data layer compared with 7 for mutation status.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher FASLG RNA is associated with better overall survival. In most high-consensus cancer types, elevated FASLG expression acts as an unfavorable survival marker, although some lineages such as SKCM and UCEC show a favorable association.

SKCM, UCEC, and HNSC are the cancer types where FASLG RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.434	0.257	<.001	147	view →
UCEC	OS	Median	All	0.760	0.599	<.001	114	view →
HNSC	DFS	Tertile	All	0.768	0.628	<.001	76	view →
BRCA	OS	Median	II,III,IV	0.609	0.518	.001	68	view →
KIRP	DFS	Quartile	All	0.442	0.710	<.001	64	view →
UVM	DFS	Median	All	0.367	0.749	<.001	60	view →
ACC	DFS	Tertile	All	0.769	0.347	<.001	46	view →
BLCA	OS	Tertile	All	0.508	0.317	.010	42	view →
THYM	OS	Median	All	0.731	1.000	<.001	39	view →
LGG	OS	Tertile	All	0.701	0.861	<.001	38	view →
LIHC	OS	Tertile	III,IV	0.764	0.294	.003	25	view →
COAD	DFS	Median	All	0.761	0.615	.015	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

FASLG–SKCM (OS)

Open the SKCM breakdown →