FASLG

Across TCGA pan-cancer cohorts, FASLG RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of FASLG’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where FASLG RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FASLG is over-expressed in tumor, although a few such as LUSC and COAD show the opposite, repressed pattern.

KIRC, STAD, and LUSC are the cancer types where FASLG tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FASLG RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+1.887	<.001	12	view →
STAD	All	II,III,IV	+0.720	.012	5	view →
LUSC	All	All	−0.598	<.001	5	view →
COAD	All	All	−0.429	.007	2	view →
KIRP	All	All	+0.419	.004	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

FASLG–KIRC

Open the KIRC breakdown →