FASLG

Across TCGA cell cohorts, FASLG mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FASLG-associated genes across cancer lineages are TMCO5A, EPPIN, and HHLA1. Each is linked with FASLG in more than 1 cancer types. Because this analysis shows association rather than direction, both FASLG-to-partner and partner-to-FASLG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMCO5A grouped by FASLG-low versus FASLG-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FASLG→partner) and Y-score (partner→FASLG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TMCO5A →	+0.019	+4.415	<.001	.007	3	1
BLOOD_Leukemia	EPPIN →	+0.012	+5.507	<.001	<.001	3	1
BLOOD_Leukemia	HHLA1 →	+0.011	+4.551	<.001	.004	3	1
BLOOD_Leukemia	OR1L3 →	+0.057	+4.276	.008	.007	3	1
BLOOD_Leukemia	OR10V1 →	+0.035	+5.569	<.001	.001	3	1
BLOOD_Leukemia	RXFP3 →	+0.018	+4.874	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

TMCO5A by FASLG expression — LARGE_INTESTINE

Explore this box plot interactively →