FANCI

Across TCGA patient cohorts, FANCI RNA expression is significantly associated with the protein abundance of many other proteins, with 25,859 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible FANCI-associated proteins across cancer lineages are RPL12_S38, RRM2, and SMC2. Each is linked with FANCI in more than 9 cancer types. Because this analysis shows association rather than direction, both FANCI-to-partner and partner-to-FANCI results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FANCI versus RPL12_S38 in LUAD, with a Pearson correlation of 0.72.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (FANCI→partner) and Y-score (partner→FANCI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RPL12_S38 →	+1.256	+0.957	<.001	<.001	3	10
LUAD	RRM2 →	+0.927	+1.031	<.001	<.001	3	10
UCEC	SMC2 →	+0.768	+0.913	<.001	<.001	3	10
GBM	SMC4 →	+0.713	+0.980	<.001	<.001	3	10
OV	BAZ1B_S349 →	+1.137	+0.810	.003	.008	3	10
LUAD	TOP2A →	+1.112	+1.012	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 25,859 associations by consensus.

FANCI vs RPL12_S38 — LUAD

Explore this scatter interactively →