FANCE

Across TCGA cell cohorts, FANCE mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FANCE-associated genes across cancer lineages are APOL5, TACR3, and SOX1. Each is linked with FANCE in more than 1 cancer types. Because this analysis shows association rather than direction, both FANCE-to-partner and partner-to-FANCE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, APOL5 grouped by FANCE-low versus FANCE-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FANCE→partner) and Y-score (partner→FANCE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	APOL5 →	+0.020	+5.475	<.001	<.001	3	1
BLOOD_Leukemia	TACR3 →	+0.028	+4.060	<.001	.003	3	1
BLOOD_Leukemia	SOX1 →	+0.565	+4.564	<.001	.001	3	1
BLOOD_Leukemia	SMIM23 →	+0.018	+4.984	<.001	.002	3	1
LUNG_NSCLC_LUAD	SCN10A →	+0.004	+4.662	<.001	.005	3	1
LARGE_INTESTINE	OR52H1 →	+0.020	+3.347	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

APOL5 by FANCE expression — BLOOD_Leukemia

Explore this box plot interactively →