FANCE

Across TCGA pan-cancer cohorts, FANCE RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of FANCE’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where FANCE RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FANCE is over-expressed in tumor, although a few such as BRCA and KICH show the opposite, repressed pattern.

HNSC, COAD, and LIHC are the cancer types where FANCE tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FANCE RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+1.486	<.001	12	view →
COAD	Female	II,III,IV	+0.939	<.001	11	view →
LIHC	Female	II,III,IV	+1.610	<.001	9	view →
BLCA	All	All	+0.802	<.001	9	view →
LUSC	Female	All	+2.020	<.001	8	view →
CHOL	All	II,III,IV	+2.809	<.001	5	view →
STAD	All	II,III,IV	+0.813	<.001	5	view →
LUAD	All	All	+0.248	.012	5	view →
THCA	Male	II,III,IV	+0.408	.008	4	view →
BRCA	Female	All	−0.348	<.001	4	view →
READ	All	All	+0.393	.007	2	view →
KICH	Female	All	−0.530	.013	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

FANCE–HNSC

Open the HNSC breakdown →