FANCD2OS

Across TCGA patient cohorts, FANCD2OS mutation is significantly associated with the RNA expression of many other genes, with 104 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FANCD2OS-associated genes across cancer lineages are OR1D4, RN7SL424P, and KRASP1. Each is linked with FANCD2OS in more than 1 cancer types. Because this analysis shows association rather than direction, both FANCD2OS-to-partner and partner-to-FANCD2OS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1D4 grouped by FANCD2OS-low versus FANCD2OS-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FANCD2OS→partner) and Y-score (partner→FANCD2OS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	OR1D4 →	+0.031	+4.800	.007	.006	3	2
SKCM	RN7SL424P →	+0.136	+5.328	<.001	.003	3	2
LUAD	KRASP1 →	+0.142	+5.279	<.001	.006	3	2
SKCM	MIR5787 →	+0.522	+4.513	<.001	.009	3	2
BLCA	IGBP1P3 →	+0.140	+4.363	<.001	.007	3	2
BLCA	RN7SKP40 →	+0.128	+4.588	.002	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 104 associations by consensus.

OR1D4 by FANCD2OS expression — BRCA

Explore this box plot interactively →