FANCD2OS

Across TCGA pan-cancer cohorts, FANCD2OS RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated FANCD2OS data layer compared with 3 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher FANCD2OS RNA is associated with worse overall survival. In most high-consensus cancer types, elevated FANCD2OS expression acts as an unfavorable survival marker, although some lineages such as SKCM and UVM show a favorable association.

KIRC, ACC, and LGG are the cancer types where FANCD2OS RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Quartile	All	0.481	0.699	<.001	125	view →
ACC	OS	Median	All	0.761	0.948	<.001	67	view →
LGG	DFS	Median	All	0.647	0.799	<.001	53	view →
SKCM	DFS	Median	II,III,IV	0.766	0.597	<.001	36	view →
MESO	DFS	Median	All	0.215	0.582	.005	30	view →
UVM	OS	Tertile	All	0.902	0.407	.027	27	view →
BLCA	DFS	Median	III,IV	0.238	0.484	.003	26	view →
LUSC	OS	Median	All	0.808	0.712	.006	21	view →
PCPG	OS	Quartile	All	0.733	1.000	.002	16	view →
CHOL	OS	Median	IV	0.208	0.948	.010	15	view →
HNSC	OS	Median	II,III,IV	0.783	0.706	.016	15	view →
READ	OS	Median	All	0.861	0.474	.003	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

FANCD2OS–KIRC (OS)

Open the KIRC breakdown →