FANCD2OS

Across TCGA pan-cancer cohorts, FANCD2OS RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of FANCD2OS’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where FANCD2OS RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FANCD2OS is over-expressed in tumor, although a few such as HNSC and KICH show the opposite, repressed pattern.

BLCA, LUAD, and COAD are the cancer types where FANCD2OS tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FANCD2OS RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	All	+0.150	.002	8	view →
LUAD	All	All	+0.140	<.001	7	view →
COAD	All	II,III,IV	+0.115	<.001	7	view →
UCEC	All	II,III,IV	+0.251	<.001	6	view →
LUSC	Female	II,III,IV	+0.130	<.001	6	view →
READ	All	II,III,IV	+0.165	.041	4	view →
BRCA	All	All	+0.137	.003	4	view →
CHOL	Male	All	+0.081	.016	4	view →
HNSC	All	II,III,IV	−0.039	.016	3	view →
LIHC	All	All	+0.017	.021	3	view →
PRAD	All	All	+0.047	.046	2	view →
STAD	All	All	+0.094	.026	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

FANCD2OS–BLCA

Open the BLCA breakdown →