FANCD2OS

Across TCGA cell cohorts, FANCD2OS RNA expression is significantly associated with the go_rna of many other GO terms, with 1,333 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible FANCD2OS-associated GO terms across cancer lineages are Mitotic DNA replication, Leading strand elongation, and Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway. Each is linked with FANCD2OS in more than 6 cancer types. Because this analysis shows association rather than direction, both FANCD2OS-to-partner and partner-to-FANCD2OS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitotic DNA replication grouped by FANCD2OS-low versus FANCD2OS-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FANCD2OS→partner) and Y-score (partner→FANCD2OS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Mitotic DNA replication →	+0.074	+0.069	<.001	.008	3	7
SOFT_TISSUE	Leading strand elongation →	+0.124	+0.095	.001	.002	3	6
KIDNEY	Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway →	-0.120	-0.035	<.001	.009	3	5
LIVER	Regulation of DNA repair →	+0.083	+0.120	<.001	<.001	3	5
LUNG_NSCLC_LUAD	Xenobiotic metabolic process →	-0.053	-0.124	.007	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	Regulation of DNA replication →	+0.059	+0.063	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,333 associations by consensus.

Mitotic DNA replication by FANCD2OS expression — BLOOD_Lymphoma

Explore this box plot interactively →