FAM9B

Across TCGA patient cohorts, FAM9B mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM9B-associated genes across cancer lineages are mTOR_pS2448, PCNA, and CDK1. Each is linked with FAM9B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM9B-to-partner and partner-to-FAM9B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by FAM9B-low versus FAM9B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM9B→partner) and Y-score (partner→FAM9B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.134	-3.156	.019	.018	3	2
UCEC	PCNA →	+0.226	+2.807	.006	.003	3	2
UCEC	CDK1 →	+0.179	+1.700	.002	.042	3	2
UCEC	Cyclin-B1 →	+0.637	+3.584	.003	.002	3	2
UCEC	14-3-3_beta →	-0.098	-1.664	.011	.023	3	1
UCEC	eIF4G →	+0.302	+1.678	.011	.023	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

mTOR_pS2448 by FAM9B expression — UCEC

Explore this box plot interactively →