FAM86DP

Across TCGA patient cohorts, FAM86DP RNA expression is significantly associated with the go_rna of many other GO terms, with 7,134 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible FAM86DP-associated GO terms across cancer lineages are Maturation of SSU-rRNA, Protein localization to cilium, and Endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Each is linked with FAM86DP in more than 18 cancer types. Because this analysis shows association rather than direction, both FAM86DP-to-partner and partner-to-FAM86DP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Maturation of SSU-rRNA grouped by FAM86DP-low versus FAM86DP-high in LAML.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM86DP→partner) and Y-score (partner→FAM86DP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LAML	Maturation of SSU-rRNA →	+0.050	+0.522	<.001	<.001	3	19
THYM	Protein localization to cilium →	+0.038	+0.718	<.001	<.001	3	18
LAML	Endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.072	+0.552	<.001	<.001	3	18
DLBC	Regulation of translational fidelity →	+0.052	+0.768	<.001	.001	3	18
TGCT	Negative regulation of hippo signaling →	+0.059	+0.567	<.001	<.001	3	17
LAML	Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.054	+0.368	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,134 associations by consensus.

Maturation of SSU-rRNA by FAM86DP expression — LAML

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