FAM86DP

Across TCGA pan-cancer cohorts, FAM86DP RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of FAM86DP’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where FAM86DP RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FAM86DP is over-expressed in tumor, although a few such as BRCA and KICH show the opposite, repressed pattern.

THCA, COAD, and LIHC are the cancer types where FAM86DP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM86DP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	+1.112	<.001	10	view →
COAD	Male	All	+0.610	<.001	9	view →
LIHC	Female	II,III,IV	+0.690	<.001	8	view →
LUAD	All	II,III,IV	+0.522	<.001	7	view →
KIRP	Female	All	+0.886	<.001	6	view →
BRCA	Female	II,III,IV	−0.511	<.001	6	view →
CHOL	All	All	+1.400	.003	4	view →
KICH	All	All	−0.684	<.001	4	view →
UCEC	All	All	−0.665	<.001	2	view →
LUSC	Female	All	−0.500	.011	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

FAM86DP–THCA

Open the THCA breakdown →