FAM86DP

Across TCGA patient cohorts, FAM86DP mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM86DP-associated genes across cancer lineages are STAT3_pY705, Tuberin, and Chk2. Each is linked with FAM86DP in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM86DP-to-partner and partner-to-FAM86DP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by FAM86DP-low versus FAM86DP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM86DP→partner) and Y-score (partner→FAM86DP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.400	-3.459	.002	.005	3	1
UCEC	Tuberin →	+0.313	+3.459	.020	.005	3	1
UCEC	Chk2 →	-0.250	-3.459	.033	.005	3	1
UCEC	Caspase-8 →	-0.250	-3.000	.048	.036	2	1
UCEC	CD49b →	-0.354	-3.150	.013	.019	2	1
UCEC	Gab2 →	+0.394	+2.321	.028	.035	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

STAT3_pY705 by FAM86DP expression — UCEC

Explore this box plot interactively →