FAM83H

Across TCGA patient cohorts, FAM83H mutation is significantly associated with the RNA expression of many other genes, with 1,775 significant associations in total. COAD shows the largest number of these associations.

The most reproducible FAM83H-associated genes across cancer lineages are RPL22P11, ZNF736P7Y, and CMC2. Each is linked with FAM83H in more than 2 cancer types. Because this analysis shows association rather than direction, both FAM83H-to-partner and partner-to-FAM83H results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL22P11 grouped by FAM83H-low versus FAM83H-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM83H→partner) and Y-score (partner→FAM83H) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RPL22P11 →	+0.166	+1.956	<.001	.006	3	3
STAD	ZNF736P7Y →	+0.056	+3.621	.001	.006	3	3
UCEC	CMC2 →	+0.414	+3.235	<.001	<.001	3	3
UCEC	MRPS15 →	+0.387	+2.849	.001	.001	3	3
SKCM	NYNRIN →	-0.917	-3.449	.005	.005	3	3
BLCA	GCSHP1 →	+0.071	+3.618	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,775 associations by consensus.

RPL22P11 by FAM83H expression — COAD

Explore this box plot interactively →