FAM83H

Across TCGA pan-cancer cohorts, FAM83H RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of FAM83H’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where FAM83H RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FAM83H is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, COAD, and STAD are the cancer types where FAM83H tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM83H RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+1.633	<.001	12	view →
COAD	All	III,IV	+1.476	<.001	12	view →
STAD	All	II,III,IV	+2.582	<.001	10	view →
LIHC	Male	III,IV	+2.205	<.001	9	view →
LUAD	Female	III,IV	+1.677	<.001	9	view →
BLCA	Male	III,IV	+4.019	.004	8	view →
LUSC	Male	III,IV	+3.047	<.001	8	view →
UCEC	All	All	+2.900	<.001	6	view →
BRCA	All	III,IV	+1.901	<.001	6	view →
CHOL	Male	All	+3.003	<.001	5	view →
KICH	All	All	−0.728	.002	5	view →
READ	All	All	+1.316	.002	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

FAM83H–HNSC

Open the HNSC breakdown →