FAM83E

Across TCGA patient cohorts, FAM83E mutation is significantly associated with the RNA expression of many other genes, with 2,452 significant associations in total. COAD shows the largest number of these associations.

The most reproducible FAM83E-associated genes across cancer lineages are AOC2, LINC00560, and TP73-AS2. Each is linked with FAM83E in more than 2 cancer types. Because this analysis shows association rather than direction, both FAM83E-to-partner and partner-to-FAM83E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AOC2 grouped by FAM83E-low versus FAM83E-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM83E→partner) and Y-score (partner→FAM83E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AOC2 →	+1.012	+3.329	<.001	.005	3	3
BLCA	LINC00560 →	+0.167	+5.033	<.001	.003	3	2
SKCM	TP73-AS2 →	+0.122	+2.365	<.001	.007	3	2
SKCM	RN7SL504P →	+0.032	+4.025	<.001	.007	3	2
COAD	MTCYBP40 →	+0.220	+3.018	<.001	.008	3	2
COAD	NCR1 →	+0.353	+2.732	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,452 associations by consensus.

AOC2 by FAM83E expression — UCEC

Explore this box plot interactively →